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Effect of mutagen-induced cell lethality on the dose response of germline mutations

✍ Scribed by William R. Lee; Dana C. Perantie; Kristin B. Clark; Dixie A. Guillot; Vincent L. Wilson

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
48 KB
Volume
37
Category
Article
ISSN
0893-6692

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The alkaline single cell gel electrophoresis (SCG test or comet assay) was used to characterize the influence of sodium arsenite (NaAsO?) and cadmium sulphate (CdS04) on the persistence of mutagen-induced DNA lesions. Human blood and SV40transformed fibroblasts (MRCSCVI ) were treated for 2 hr with