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Effect of multiplicative and additive noise on genetic transcriptional regulatory mechanism

✍ Scribed by Xue-Mei Liu; Hui-Zhang Xie; Liang-Gang Liu; Zhi-Bing Li

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
640 KB
Volume
388
Category
Article
ISSN
0378-4371

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✦ Synopsis

A multiplicative noise and an additive noise are introduced in the kinetic model of Smolen-Baxter-Byrne [P. Smolen, D.A. Baxter, J.H. Byrne, Amer. J. Physiol. Cell. Physiol. 274 (1998) 531], in which the expression of gene is controlled by protein concentration of transcriptional activator. The Fokker-Planck equation is solved and the steady-state probability distribution is obtained numerically. It is found that the multiplicative noise converts the bistability to monostability that can be regarded as a noise-induced transition. The additive noise reduces the transcription efficiency. The correlation between the multiplicative noise and the additive noise works as a genetic switch and regulates the gene transcription effectively.

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