Effect of morphine and its ethers on the hyperkinesis caused by barbiturates
β Scribed by V. M. Karasik; I. V. Markova
- Publisher
- Springer US
- Year
- 1956
- Tongue
- English
- Weight
- 73 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0007-4888
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,
The disposition of morphine (MOR) and its metabolites in the rabbit was measured after topical administration of its hydrochloride salt (MOR. HCI), and their time course was compared with those after intravenous and oral administration. The area under the plasma concentration-time curve (AUC) ratio
The deformation of solid surfaces caused by the Laplace pressure is analyzed ad its effect on the meniscus force measurement is discussed by comparing it with the published experimental results of the meniscus force on a surface force apparatus. It is found theoretically that the deformation reaches