Effect of molecular interaction on permeation of organic molecules through dimethyl polysiloxane membrane

✍ Scribed by Masahiro Nakano; Nagin K. Patel

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 606 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590113

✦ Synopsis

In order to investigate the nature of permeation of organic molecules through a nonpolar membrane in the presence of other molecular species, some model studies have been made with p-nitrophenol as an ionizable diffusate and N,N-dialkylamides and alkylxanthines as complexing agents. Effect of diethylpropionamide on permeation of salicylic acid was also examined. 8-Methoxycaffeine and caffeine were used as model compounds for nonionizable molecules and permeability constants were determined with and without complexing agents. The permeability of a diffus'ate increased in the presence of complexing agents which interact strongly with the diffusate in nonpolar environments, whileit decreased in the case of the agents which complex with the diffusate mainlv in aaueous solution.

Keyphrases 0 Molecules, organic4imethyl polysiloxane