Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully β£-helical one, and one where 87-90 form a typ
Effect of molecular confinement on internal enzyme dynamics: Frequency domain fluorometry and molecular dynamics simulation studies
β Scribed by Ettore Bismuto; Pier Luigi Martelli; Anna De Maio; Damiano Gustavo Mita; Gaetano Irace; Rita Casadio
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2002
- Tongue
- English
- Weight
- 660 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0006-3525
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## RNase A has been extensively used as a model protein in several biophysical and biochemical studies. Using the available structural and biochemical results, RNase A-UpA interaction has been computationally modeled at an atomic level. In this study, the molecular dynamics (MD) simulations of nativ