Effect of modification by N-acetoxy-N-2-acetylaminofluorene on the level of DNA methylation
β Scribed by SALAS, C. E.; PFOHL-LESZKOWICZ, A.; DIRHEIMER, G.; LANG, M. C.
- Book ID
- 109713254
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 210 KB
- Volume
- 278
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/278071a0
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DNA adduct induction by N-acetoxy-N-2-acetylaminofluorene (N-Ac-AAF) has been investigated in Chinese hamster ovary (CHO) cells using immunoelectron microscopy. The major RNA and DNA adducts, N-(guanosin-8-yl)-2-aminofluorene (G-C8-AF) and N-(deoxyguanosin-8-yI)-2-aminofluorene (dG-C8-AF), were loca
## Abstract The effect of ribose(O2β²)βmethylation on the stability of (O2β²)βmethylated polyribonucleotide helices has been studied by conformational energy calculations. The preferred orientation of the methyl group is found to further stabilize the helical phosphodiester conformation (__g__^β^,__g