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Effect of Mineral Trioxide Aggregate Cements on Transforming Growth Factor β1 and Bone Morphogenetic Protein Production by Human Fibroblasts In Vitro

✍ Scribed by Gunseli Guven; Zafer C. Cehreli; Ali Ural; Muhittin A. Serdar; Feridun Basak

Book ID: 116676843
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 256 KB
Volume: 33
Category: Article
ISSN: 0099-2399
DOI: 10.1016/j.joen.2006.12.020

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## Abstract ## Objective Bone morphogenetic protein (BMP) and transforming growth factor β (TGFβ) are potent anabolic factors in adult articular chondrocytes. In this study, we investigated whether intracellular inhibitors of BMP and TGFβ signaling, inhibitory Smad6 (I‐Smad6) and I‐Smad7, are expr