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Effect of Milk Thistle on the Pharmacokinetics of Indinavir in Healthy Volunteers

โœ Scribed by Stephen C. Piscitelli; Elizabeth Formentini; Aaron H. Burstein; Raul Alfaro; Shyla Jagannatha; Judith Falloon

Book ID
115048576
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
48 KB
Volume
22
Category
Article
ISSN
0277-0008

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โœ Kaori Morimoto; Kozue Kishimura; Takaaki Nagami; Nao Kodama; Yoichiro Ogama; Mid ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 240 KB ๐Ÿ‘ 1 views

We previously showed that oseltamivir, a prodrug of the influenza virus neuraminidase inhibitor Ro 64-0802, is a substrate of proton-coupled oligopeptide transporter (PEPT1), and its intestinal absorption in rats is markedly inhibited by administration with milk. To investigate the importance of PEP