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Effect of microtubule inhibitors on the tubulin system of Dictyostelium discoideum

✍ Scribed by S. Rubino; E. Unger; G. Fogu; Dr. P. Cappuccinelli

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
634 KB
Volume
22
Category
Article
ISSN
0233-111X

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✦ Synopsis

Abstract

Indirect immunofluorescence with antibodies to microtubular proteins has been used to investigate the microtubule system of Dictyostelium discoideum vegetative amoebae and the action of several compounds that interfere with that system. All the inhibitors tested show an antimicrotubular effect.

Colchicine, vinblastine, nocodazole, thiabendazole, and isopropyl‐N‐phenyl‐carbamate (IPC) seem to act mainly by destroying microtubules leaving the appearance of nuclei associated organelles (NAOs) undisturbed. On the other hand griseofulvin also affects NAOs which disappear in treated cells.

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