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Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers

โœ Scribed by Kyoung-Ah Kim; Ji-Young Park

Publisher
Springer
Year
2010
Tongue
English
Weight
125 KB
Volume
66
Category
Article
ISSN
0031-6970

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Effect of milk on the pharmacokinetics o
Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers
โœ Kaori Morimoto; Kozue Kishimura; Takaaki Nagami; Nao Kodama; Yoichiro Ogama; Mid ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 240 KB ๐Ÿ‘ 1 views

We previously showed that oseltamivir, a prodrug of the influenza virus neuraminidase inhibitor Ro 64-0802, is a substrate of proton-coupled oligopeptide transporter (PEPT1), and its intestinal absorption in rats is markedly inhibited by administration with milk. To investigate the importance of PEP