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Effect of methyl substitution on protein tertiary structure

✍ Scribed by Woon Ki Paik; Sangduk Kim

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
358 KB
Volume
155
Category
Article
ISSN
0022-5193

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✦ Synopsis

Biological effects caused by the post-translational methylation of certain side chains in proteins has been thought to be due solely to changes in charge, steric relations or hydrophobicity at the site of the methyl group. However, there is increasing evidence that the presence of CH3 can also induce a "global" effect on the protein molecule. Some of the evidence is described in this paper.

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## Abstract The consequences of substitution of fluorine for the __para__ hydrogen of a phenylalanine residue in ribonuclease‐S were investigated by conformational energy calculations using the AMBER force field. Both the fluorine‐containing protein and the corresponding nonfluorinated material wer