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Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats

✍ Scribed by Yoshihiko Shibayama; Kazami Ushinohama; Ryuji Ikeda; Yoshimi Yoshikawa; Toshiro Motoya; Yasuo Takeda; Katsushi Yamada

Book ID: 108583741
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 246 KB
Volume: 97
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2006.00304.x

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Effect of ursodeoxycholic acid (UDCA) treatment on the expression and function of intestinal multidrug resistance-associated protein (Mrp) 2 was examined in rats. When rats were orally administered 0.5% UDCA solution for 6 days, mRNA and protein levels of Mrp2 in the intestine were increased about t