Effect of methotrexate on the deoxyuridine suppression test: Results with different cell preparations

The effect of different TP53 mutations o

The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 activity, before and after DNA damage

✍ Ann C. Williams; Jayne C. Miller; Tracey Collard; Sara J. Browne; Robert F. Newb 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 1 views

We examined the effect of loss of wild type TP53 activity on the chromosomal stability of a human colonic adenoma derived cell line (designated AA/C1) by studying transfected variants which express different TP53 mutations. Using gross chromosomal aberrations as a measure of instability, we studied