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Effect of metal hydride and silica gel on the sharpless asymmetric epoxidation

✍ Scribed by Wang Zhi-min; Zhou Wei-Shan; Lin Guo-qiang

Book ID
104226930
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
193 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis

The reaction time of asymmetric epoxidation of allylic alcohol was greatly reduced when a catalytic amount of both metal hydride and silica gel was occurred in the Sharpless reagent.

An efficient method for the asymmetric epoxidation of allylic alcohol Using Sharpless reagent [Ti(OiPrj4, (+)-or (-)-diethyl tartrate (DET) and tert-butylhydroperoxide (TBBP)]l-3 is extremely useful in the synthesis of chiral com-

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Application of Sharpless asymmetric epox
Application of Sharpless asymmetric epoxidation on the preparation of the optically active flavours 3-methylthiohexanal and 5(6)-butyl-1,4-dioxan-2-one
✍ Hong-yu Tian; Bao-guo Sun; Li-wei Tang; Hong-lin Ye 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

## Abstract Optically active 2,3‐epoxyhexanol obtained from Sharpless asymmetric epoxidation (AE) was regioselectively reduced to 1,3‐hexandiol or 1,2‐hexandiol. 1,3‐Hexandiol was converted to 3‐mesyloxyhexyl acetate. The following reaction with CH~3~SK gave 3‐methylthiohexanol, which was oxidized