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Effect of metal-based anticancer drugs on wild type and metallothionein null cell lines

โœ Scribed by H. Mahboobi; A. Viarengo; D. Colangelo; D. Osella


Book ID
110422365
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
94 KB
Volume
16
Category
Article
ISSN
1572-8773

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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib