The incidence of Down syndrome (DS) at conception is highly dependent on the maternal age distribution and age-specific pregnancy rates. The live birth prevalence of DS reflects these factors and fetal deaths. This study examined DS live birth prevalence from 1983 to 1992 in New York State and analy
Effect of maternal age distribution and prenatal diagnosis on the population rates of Down syndrome - a comparative study of nineteen populations
✍ Scribed by BENGT KÄLLEN; LISBETH B. KNUDSEN
- Book ID
- 114809356
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 424 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0018-0661
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We aimed to determine how differences in the age at which women had their pregnancies influenced the expected detection and false-positive rates of serum screening for Down 's syndrome (i) between 1970 and 1993 in England and Wales, and (ii) between regions and districts of England and Wales in 1991
Precision and accuracy in determining rates of Down syndrome at livebirth are indispensible to algorithms which determine eligibility for prenatal cytogenetic diagnostic services. W e derived Down syndrome rates by single year of maternal age which we propose as a revised rate schedule for backgroun