Effect of low grade radiofrequency heating on arterial vasospasm in the porcine model

✍ Scribed by Mitchel, Joseph F. ;McKay, Raymond G. ;Azrin, Michael A. ;Aretz, Thomas A. ;Waters, David D. ;Fram, Daniel B.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 405 KB
• Volume: 42
• Category: Article
• ISSN: 0098-6569
• DOI: 10.1002/(sici)1097-0304(199711)42:3<348::aid-ccd28>3.0.co;2-g

✦ Synopsis

Nineteen pigs were studied in order to assess the effect of low grade, radiofrequencypowered, thermal balloon angioplasty on the vasoconstrictor response of peripheral arteries. A mechanical stimulus was used to induce vasospasm. Thermal angioplasty reduced the extent of inducible vasospasm from 79% to 6% compared to nonthermal control inflations, which reduced the vasoconstrictor response from 75% to 60% (P F 0.001). Histologic studies demonstrated that the extent of myocyte necrosis was significantly greater in the thermally treated arteries than in the control vessels (P F 0.01). Thermal balloon angioplasty at 60°C significantly attenuates peripheral arterial vasospasm induced by mechanical trauma in the porcine model. This paralytic effect may be related to the loss of myocytes secondary to thermal necrosis.