✦ LIBER ✦

Effect of long-term physical aging on the kinetic parameters in a common pharmaceutical drug: Flutab®

✍ Scribed by A.A. Abu-Sehly; A.A. Elabbar

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 415 KB
Volume: 406
Category: Article
ISSN: 0921-4526
DOI: 10.1016/j.physb.2010.10.032

No coin nor oath required. For personal study only.

✦ Synopsis

Differential scanning calorimetry (DSC) measurements were performed to investigate the effects of longterm physical aging on kinetic parameters of the pharmaceutical drug (Flutab s ). Kinetics parameters such as activation energy (E) and fragility parameter (m) of the glass transition for aged and rejuvenated glasses were determined using different kinetic models. Evidence of variation of E with temperature is presented. It is shown in this work that natural storage of the drug introduced significant physical aging as indicated by changes in the glass transition temperature, activation energy and fragility parameter.

📜 SIMILAR VOLUMES

The effect of physical aging on long-ter

The effect of physical aging on long-term properties of poly-ether-ketone (PEEK) and PEEK-based composites

✍ A. D'Amore; F. Cocchini; A. Pompo; A. Apicella; L. Nicolais 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 620 KB

## Abstract The viscoelastic properties of the amorphous and semicrystalline PEEK and of a PEEK‐based composite (APC2) have been analyzed as a function of the aging time and related free volume relaxation, at temperatures close to the glass transition temperature. The effect of thermal treatments (

A new approach of drug design based on t

A new approach of drug design based on the determination of a minimum set of common parameters in terms of molecular surface electrostatic potentials for compounds with the same therapeutic activities: case of neuroactive agents

✍ G Pepe 📂 Article 📅 1986 🏛 Elsevier Science 🌐 English ⚖ 328 KB