Effect of lomeguatrib–temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells
✍ Scribed by Taspinar, Mehmet; Ilgaz, Seda; Ozdemir, Mevci; Ozkan, Tulin; Oztuna, Derya; Canpinar, Hande; Rey, Juan A.; SunguroÄlu, Asuman; Castresana, Javier S.; Ugur, Hasan Caglar
- Book ID
- 120061356
- Publisher
- S. Karger AG
- Year
- 2013
- Tongue
- English
- Weight
- 710 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1010-4283
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## Abstract Epigenetic silencing of the O^6^‐methylguanine‐DNA methyltransferase (__MGMT__) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methyl
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