The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1)
Effect of Liuwei Dihuang decoction () on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats
โ Scribed by Zhou Jianzheng; Zhang Yongxiang; Liu Chuanhui; Zhou Jinhuang
- Publisher
- Chinese Association of Traditional and Western Medicine
- Year
- 1999
- Tongue
- English
- Weight
- 543 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1672-0415
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This report evaluates two morphological markers of synaptogenesis following the induction of long-term potentiation (LTP) in the dentate gyrus of the anesthetized rat. These two morphological features, polyribosomes and multiple synaptic contacts, are known to increase in number with synaptogenesis
Long-term potentiation (LTP) was examined in the CA1 region of rat hippocampal slices at postnatal day 9 (P9), P15, P30, P60, P90, P120, and P300. A single 100 H z x 1 sec tetanus failed to induce LTP in P9 slices, while similar degrees of LTP were observed at P15, P30, and P60. At P30, changes in p