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Effect of lithium on the double-quantum behavior of 23na in normal human erythrocytes

✍ Scribed by Rao P. Gullapalli; Roger M. Hawk; Richard A. Komorosk

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
714 KB
Volume
27
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The doublé‐quantum behavior of ^23^Na in the presence of different concentrations of Li in human erythrocytes was investigated. The ^23^Na double‐quantum signal was quenched in both the extracellular and the intracellular compartments with increasing concentration of Li in each compartment, along with an increase in the ^23^Na T~1~ both intra‐ and extracellularly. Some extracellular quenching could be observed at the near therapeutic concentration of 2 m__M__ Li. The ratio of slow to fast spin‐spin (T~2~) relaxation times, obtained from the dependence of the double‐quantum signal on creation time, approached unity at an overall Li concentration of 40 m__M.__ These results provide evidence that Li and Na compete for both intra‐ and extracellular binding sites in erythrocytes.

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