Effect of liposomal interleukin-2 on ascites-forming rat hepatoma

✍ Scribed by Dr. Hiroyuki Konno; Yuji Maruo; A. F. Matin; Tatsuo Tanaka; Satoshi Nakamura; Shozo Baba; Akira Yamashita; Takushi Tadakuma

• Book ID: 102438824
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 399 KB
• Volume: 51
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930510110

✦ Synopsis

Interleukin-2 was entrapped in liposomes (Lip-IL-2) and injected into rats. The intraperitoneal injection of Lip-IL-2 into rats bearing an ascites-forming rat hepatoma (AH-66) significantly increased the survival time when compared with rats administered free TL-2 or saline-containing liposomes. The number of peritoneal excudate cells (PEC) increased markedly after intraperitoneal injection of Lip-1L-2 and consisted mainly of macrophages. The level of tumor necrosis factor a (TNF-a) and the intensity of free radicals increased in the ascites at 48 hrs after Lip-IL-2 administration, whereas TNF-a was not detected and the intensity of free radicals did not increase after free IL-2 administration. Our findings suggested that entrapment of IL-2 into liposomes enhanced its potential for cancer therapy, presumably by activating macrophages to produce TNF-a and free radicals.