Effect of Lipid with Covalently Attached Poly(ethylene glycol) on the Surface Properties of Liposomal Bilayer Membranes
β Scribed by Yoshida, Ayumi; Hashizaki, Kaname; Yamauchi, Hitoshi; Sakai, Hideki; Yokoyama, Shoko; Abe, Masahiko
- Book ID
- 126305261
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 161 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0743-7463
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The effectiveness of the covalent modification of a-chymotrypsin with methoxy poly(ethylene glycol) (PEG) to afford its stabilization during encapsulation in poly(lactic-co-glycolic) acid (PLGA) microspheres by a solid-in-oil-in-water method was investigated. a-Chymotrypsin was chemically modified w
Encapsulation of proteins in polyester microspheres by coacervation methods frequently causes protein inactivation and aggregation. Furthermore, an often-substantial amount of the encapsulated proteins is released within the first 24 h from the microspheres. To overcome these problems poly(ethylene