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Effect of leukotriene receptor antagonists on lung fibrosis in rats

✍ Scribed by Olfat G. Shaker; Doaa A. Sourour

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
837 KB
Volume
31
Category
Article
ISSN
0260-437X

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✦ Synopsis

ABSTRACT

To compare the effects of montelukast, prednisone and the combination of both drugs in a rat model of bleomycin‐induced lung fibrosis. Rats, injected intravenously with bleomycin daily for five consecutive days, were treated with either montelukast, prednisone or a combination of both drugs orally daily for 35 days starting 14 days after the commencement of the first dose of bleomycin. Montelukast‐treated rats showed reduction in collagen deposition by 29% and significant reduction in lung hydroxyproline content by 32%. Prednisone produced nonsignificant difference in collagen deposition and in lung hydroxyproline content compared with the bleomycin group. There was also a significant reduction in collagen deposition and hydroxyproline content in montelukast and prednisone treated rats by 15 and 17%, respectively, compared with bleomycin group. A significant reduction occurred in the mean area percentage of myofibroblast α smooth muscle actin in montelukast and montelukast and prednisone‐treated groups by 41 and 37%, respectively, with nonsignificant difference in prednisone‐treated rats as compared with the bleomycin group. Montelukast may be therapeutically effective for inhibiting further progression of lung fibrosis through inhibition of α‐SMA positive myofibroblasts. Copyright © 2011 John Wiley & Sons, Ltd.

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