𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of lentinan on tumor growth in murine allogeneic and syngeneic hosts

✍ Scribed by József Zákány; Goro Chihara; József Fachet

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
510 KB
Volume
25
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of lentinan on retardation and regression of transplanted tumors was analysed in allogeneic and syngeneic tumor‐host systems. The effect of lentinan treatment was most variable in random‐bred Swiss albino mice bearing sarcoma 180. With inbred host strains, it was most effective in A/Ph and less, or not at all, in others (A.BY, A.CA, A.SW, DBA/2, BALB/c, C3H/Di, AKR, B10, B10.A, B10. BR, B10.D2). Inorder to eliminate the allogeneic differences, a syngeneic transplantable 3‐methylcholanthrene‐induced sarcoma (A/Ph.MC.SI) has been developed in the A/Ph strain, previously found to be the most responsive to lentinan. The growth of this sarcoma was dramatically inhibited and regression was detected in all lentinan‐treated syngeneic recipients. Both the lentinan‐treated and untreated regressor animals exhibited a high degree of resistance to a secondary challenge. However, the growth of a spontaneous, transplantable syngeneic adenocarcinoma in A/Ph mice was not influenced by lentinan treatment. The results presented substantiate further the conclusion that the effect of lentinan is mediated through host mechanisms, and show that these mechanisms are able to act against a syngeneic tumor.

📜 SIMILAR VOLUMES

Effect of lentinan on the production of
Effect of lentinan on the production of migration inhibitory factor induced by syngeneic tumor in mice
✍ József Zákány; Goro Chihara; József Fachet 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 530 KB

## Abstract Attempts were made to reveal the mechanism of the inhibitory effect of lentinan on methylcholanthrene‐in‐duced transplantable fibrosarcoma (A/Ph.MC.SI) isografts. Since the involvement of a delayed‐type hypersensitivity response can be supposed to operate against this syngeneic tumor, t

Inhibition of syngeneic tumor growth in
Inhibition of syngeneic tumor growth in rats immunized with allogeneic skin grafts
✍ Masuo Hosokawa; Masahiro Imamura; Tsuneyuki Oikawa; Eiki Gotohda; Takao Kodama; 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 551 KB

## Abstract The growth of a transplantable tumor (KMT‐17) in syngeneic Wistar King Aptekman/Mk (WKA) rats was inhibited by preimmunization with allogeneic normal cells from Donryu strain rats. The phenomenon is referred to as allogeneic cell immunity. A slight inhibition was observed in rats immuni

Effect of syngeneic tumor cells bound to
Effect of syngeneic tumor cells bound to concanavalin a on tumor growth
✍ A. Brugarolas; H. Takita; G. E. Moore 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 English ⚖ 489 KB

Transplanted MOPC 315 solid myelomas in BALB/cCR mice were treated with single injections of 1.6 x lo6 syngeneic MOPC 315 cells combined either with human gamma globulin or with Concanavalin A (Con A). The group of mice whch received injections of MOPC 315 cells coupled with human gamma globulin fai

Immunological characteristics of leukemi
Immunological characteristics of leukemia and lymphoma in allogeneic cell immunity: Growth of syngeneic tumors in rats immunized with allogeneic cells
✍ Masuo Hosokawa; Tetsuro Yamashita; Eiki Gotohda; Noritoshi Takeichi; Takao Kodam 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 666 KB

## Abstract The growth of transplanted tumors was strongly inhibited in syngeneic Wistar King Aptekman (WKA) rats immunized with allogeneic tumor cells from Donryu rats. This phenomenon of non‐specific immunity against tumors is referred to as “allogeneic cell immunity”. However, an exception to th