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Effect of L-thyroxine (LT4) and D-thyroxine (DT4) on cardiac function and high-energy phosphate metabolism: A 31P NMR study

✍ Scribed by G. S. Sandhu; R. Steele; N. C. Gonnella

Book ID: 102531148
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 417 KB
Volume: 18
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910180125

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✦ Synopsis

Abstract

^31^P NMR spectroscopy was used to monitor the cardiac energy metabolism in hypothyroid rat hearts. Differential alterations in phosphocreatine and inorganic phosphate levels were observed upon treatment of hypothyroid animals with DT~4~ and LT~4~, while both agents were equipotent in reducing cholesterol. These results show potential for NMR spectroscopy as a technique to determine therapeutic selectivity. © 1991 Academic Press. Inc.

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