Effect of l-ethionine on macromolecular synthesis in mitogen-stimulated lymphocytes
β Scribed by Peter Zabos; David A. Kyner; Rochelle Seide-Kehoe; George Acs; Judith K. Christman
- Book ID
- 115746835
- Publisher
- Elsevier Science
- Year
- 1978
- Weight
- 945 KB
- Volume
- 520
- Category
- Article
- ISSN
- 0005-2787
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The ability of mouse thymocytes and peripheral blood lymphocytes from rats to synthesize and secrete proteoglycans in the presence of a variety of mitogens and lymphokines was studied in vitro, and it was confirmed that such lymphocytes synthesize and secrete significant quantities of proteoglycans.
Changes in the activities of several lysosomal enzymes were studied during transformation of mouse spleen cells in vitro. The activity of p-glucuronidase increased during culture in the presence of T o r B-cell mitogens, and lymphoblasts contained higher levels of activity than did small, non-transf