Effect of kauranes from Montanoa spp. on rat uterus

✍ Scribed by Patricia Campos-Bedolla; María G. Campos; Antonio Valencia-Sánchez; Héctor Ponce-Monter; Carmen Uribe; Lidia Osuna; J. Calderón

• Book ID: 101286489
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 448 KB
• Volume: 11
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199702)11:1<11::aid-ptr936>3.0.co;2-v

✦ Synopsis

The effect of kaurenoic acid (from Montanoa frutescens), grandifloric and kauradienoic acid (from M. tomentosa) and 16␣-hydroxy-ent-kauran-19-oic acid and its methyl ester (from M. hibiscifolia) were assayed on the contractions of rat uterus induced by acetylcholine, oxytocin and serotonin. The four kauranes assayed inhibited the contractile activity induced by the three agonists through a mechanism independent of either ␤ 2 -adrenergic or H 2 -histaminergic receptors present in uterine smooth muscle. Oestrogenized uteri treated with kauradienoic acid underwent histological changes including epithelial flattening and desquamation.