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Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

✍ Scribed by R. Matthew Fesinmeyer; Sabine Hogan; Atul Saluja; Stephen R. Brych; Eva Kras; Linda O. Narhi; David N. Brems; Yatin R. Gokarn

Book ID
106493628
Publisher
Springer US
Year
2008
Tongue
English
Weight
298 KB
Volume
26
Category
Article
ISSN
0724-8741

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Silicone oil, which is used as a lubricant or coating in devices such as syringes, needles and pharmaceutical containers, has been implicated in aggregation and particulation of proteins and antibodies. Aggregation of therapeutic protein products induced by silicone oil can pose a challenge to their