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Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine

✍ Scribed by Kayoko Ohura; Toshimitsu Soejima; Ryoichi Nogata; Yasuhisa Adachi; Shin-Ichi Ninomiya; Teruko Imai

Book ID
112134589
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
251 KB
Volume
101
Category
Article
ISSN
0022-3549

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Effect of fruit juices on the oral bioav
Effect of fruit juices on the oral bioavailability of fexofenadine in rats
✍ Amrita V. Kamath; Ming Yao; Yueping Zhang; Saeho Chong πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 94 KB πŸ‘ 1 views

Fexofenadine has been identified as a substrate for both the efflux transporter, P-glycoprotein (P-gp), as well as the influx transporter, organic anion transporting polypeptide (OATP). Clinical studies in humans showed that fruit juices reduced the oral bioavailability of fexofenadine by preferenti