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Effect of Intermittent Systemic Administration of Recombinant Parathyroid Hormone (1-34) on Mandibular Fracture Healing in Rats

✍ Scribed by Henry H. Rowshan; Mary A. Parham; Dale A. Baur; RaeLynn D. McEntee; Eugene Cauley; Dane T. Carriere; Joseph C. Wood; William J. Demsar; Jose M. Pizarro

Book ID: 113739150
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 882 KB
Volume: 68
Category: Article
ISSN: 1531-5053
DOI: 10.1016/j.joms.2009.09.045

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Intermittent doses of parathyroid hormone (PTH) stimulate bone formation in animals and humans, but the molecular mechanisms underlying this phenomenon are not understood. Bone formation culminates with the expression of type I collagen, osteocalcin, and alkaline phosphatase, but genes that initiate