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Effect of interferon therapy on RNA of GB virus C in the patients with chronic hepatitis who were co-infected with hepatitis C virus

✍ Scribed by Kiyomi Yasuda; Shiro Iino

Book ID
114303896
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
625 KB
Volume
6
Category
Article
ISSN
0928-4346

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Of 74 patients who were infected with hepatitis C virus (HCV) and received interferon, 12 (16%) were positive for RNA of GB virus C (GBV-C). RNA of GBV-C was determined in sera from the co-infected patients retrospectively, and the effect of interferon on GBV-C was compared with that on HCV in them.

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Hepatitis C virus RNA as detected by reverse transcription and nested polymerase chain reaction was monitored in 16 patients with chronic hepatitis C treated with interferon. Hepatitis C virus R N A became undetectable after 4 to 8 wk of interferon administration in 13 of the 16 patients. During 6 m