𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of interaction between65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper)

✍ Scribed by Jadwiga Chmielnicka; Elżbieta Komsta-Szumska; Grażyna Zareba

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
526 KB
Volume
53
Category
Article
ISSN
0340-5761

No coin nor oath required. For personal study only.

✦ Synopsis

Interaction of zinc with mercuric chloride and sodium selenite was studied in the rat at the organ and subcellular levels (liver and kidneys). Zinc chloride was administered subcutaneously at dose of 5 mg Zn/kg, mercury chloride into the tail vein at a dose of 0.5 mg Hg/kg (both metals every other day during 2 weeks) and sodium selenite intragastrically, at doses of 0.1 mg Se/kg, every day. Zinc retention in the rat did not exceed 20% and was unchanged in the presence of mercury. An interaction effect was reflected by an increased whole-body retention of zinc by selenium, mercury, and selenium. In the presence of selenium no peak of metallothionein-like proteins stimulated by zinc or mercury was found in the soluble fraction of the kidneys. The metallothionein level did not differ from that typical for control group animals, too. A significant increase in the level of endogenous copper was found only in the kidneys of rats exposed to zinc in the presence of mercury and selenium.

📜 SIMILAR VOLUMES

Influence of selenium dose on mercury di
Influence of selenium dose on mercury distribution and retention in suckling rats
✍ Tatjana Orct; Maja Lazarus; Jasna Jurasović; Maja Blanuša; Martina Piasek; Krist 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 1 views

## Abstract It is well known that metal–metal interactions in the body are age‐dependent. We studied the influence of increasing selenium (Se) doses on mercury (Hg) distribution and retention in the postnatal period in Hg‐exposed suckling rats. Seven‐day‐old Wistar pups were pretreated with three d

Evaluation of comparative effect of pre-
Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats
✍ Rakhi Agarwal; S. Raisuddin; Shikha Tewari; Sudhir K. Goel; R. B. Raizada; Jai R 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 435 KB 👁 2 views

## Abstract To evaluate the effect of pre‐ or posttreatment of selenium (6 μmol/kg b.w., single intraperitoneal injection) in mercury intoxication, rats were exposed to mercury (12 μmol/kg b.w., single intraperitoneal injection). Exposure to mercury resulted in induced oxidative stress in liver, ki

Effect of thiocarbamate derivatives on c
Effect of thiocarbamate derivatives on copper, zinc, and mercury distribution in rats and mice
✍ Jan Aaseth; Jan Alexander; Axel Wannag 📂 Article 📅 1981 🏛 Springer-Verlag 🌐 English ⚖ 551 KB

Oral treatment of rats with tetramethylthiuram disulphide (TMTDS), 0.1% mixed in the food (corresponding to 20--30 mumol daily) for one week, increased the brain levels of endogenous copper and zinc to 120% and 170%, respectively, of the control levels. Mice injected with HgCl2 (2.5 mumol/kg) were u