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Effect of interaction between 5-azacytidine and DNA (cytosine-5) methyltransferase on C-to-G and C-to-T mutations in Escherichia coli

✍ Scribed by Kathy M.J Doiron; Johann Lavigne-Nicolas; Claire G Cupples


Book ID
114072554
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
252 KB
Volume
429
Category
Article
ISSN
0027-5107

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## Abstract The DNA repair enzyme O^6^‐methylguanine‐DNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG