Effect of Inhibitors of Nitric Oxide Synthase on Acetaminophen-Induced Hepatotoxicity in Mice
β Scribed by Jack A. Hinson; Thomas J. Bucci; Lisa K. Irwin; Sherryll L. Michael; Philip R. Mayeux
- Book ID
- 115642175
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 331 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1089-8603
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## Abstract The effect of aminoguanidine (a selective inhibitor of inducible nitric oxide synthase) on allyl alcoholβinduced liver injury was assessed by the measurement of serum ALT and AST activities and histoβ pathological examination. When aminoguanidine (50β300 mg/kg, i.p.) was administered to
Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa