Effect of inhibitors of DNA synthesis on UV-sensitive derivatives of Escherichia coli strain K-12
โ Scribed by Michael H.L. Green; John Donch; Joseph Greenberg
- Book ID
- 116036134
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 270 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0027-5107
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In studies on thymineless death in Escherichia coli K12, it was noted that certain thymine requiring mutants were inhibited by thymidine. The pattern of inhibition varied with the conditions and media employed. Accumulation of deoxyribose-5-phosphate as a possible reason for inhibition is ruled out
It was shown previously that a major class of UV-resistant derivatives of lexA- strains of E. coli K-12 is defective in cell division at 42.5 degrees. The thermosensitive mutations, judging by genetic mapping and complementation tests, are believed to be intragenic suppressor mutations that lower th