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Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats

โœ Scribed by Rex Munday; Barry L. Smith; Christine M. Munday


Book ID
113517179
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
183 KB
Volume
155
Category
Article
ISSN
0009-2797

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Haemolytic activity and nephrotoxicity o
โœ R. Munday; B. L. Smith; E. A. Fowke ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 561 KB

The short-term toxicity of 2-hydroxy-1,4-naphthoquinone (lawsone) and 2-methyl-1,4-naphthoquinone (menadione) has been compared in rats. 2-Methyl-I ,4-naphthoquinone has been shown previously to cause haemolytic anaemia in animals, and this was confirmed in the present experiment. 2-Hydroxy-l,4-nap

Structure-activity relationships in the
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## Abstract Naphthoquinone derivatives are under investigation as potential therapeutic agents. Some such compounds are known, however, to be toxic to both animals and humans. Many naphthoquinone derivatives are haemolytic agents, while others cause necrosis of tubular epithelial cells. In the pres