Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects
โ Scribed by G.J Cuskelly; H McNulty; J.M Scott
- Book ID
- 118561668
- Publisher
- The Lancet
- Year
- 1996
- Tongue
- English
- Weight
- 440 KB
- Volume
- 347
- Category
- Article
- ISSN
- 0140-6736
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## Abstract ## BACKGROUND Since the publication of randomized controlled trials demonstrating the prevention of neural tube defects (NTDs) with periconceptional folate, several Australian states have promoted an increase in periconceptional use of folic acid supplements. Since 1996, voluntary fort
## BACKGROUND: The etiology of neural tube defects (NTDs) is multifactorial, with environmental and genetic determinants. Folate supplementation prevents the majority of NTDs, and a polymorphism in methylenetetrahydrofolate reductase (MTHFR) has become recognized as a genetic risk factor. The mech