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Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line

✍ Scribed by Nicole Borth; Diethard Mattanovich; Renate Kunert; Hermann Katinger

Book ID
109387137
Publisher
American Institute of Chemical Engineers
Year
2008
Tongue
English
Weight
208 KB
Volume
21
Category
Article
ISSN
8756-7938

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## Abstract Protein disulfide isomerase (PDI), one of the ER‐resident molecular chaperones, forms and isomerizes disulfide bonds. This study attempts to investigate the effect of PDI expression level on specific productivity (__q__) of recombinant Chinese hamster ovary (rCHO) cells producing thromb