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Effect of immunosuppression or immunostimulation on the growth rate of a lymphoid and of a myeloid leukemia in mice

✍ Scribed by I. Hršak; K. Pavelić

Publisher
Springer-Verlag
Year
1977
Tongue
English
Weight
487 KB
Volume
3
Category
Article
ISSN
0340-7004

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✦ Synopsis

The influence of immunosuppression or immunostimulation on the growth rate of a lymphatic and of a myeloid murine leukemia has been investigated in syngeneic host-tumour relation. Immunosuppression by chemotherapy or X-rays, induced before transplantation of leukemia cells, did not change the survival time of the animals. Treatment with the immunosuppressive drug cortisone which is not cytostatic for these leukemias, if instituted after the transplantation of malignant cells, enhanced the growth rate of t~e lymphatic leukemia. Nonspecific stimulation with Corynebacterium parvum induced resistance to a graft of !ymphatic leukemia in a majority of the mice, but only slowed the growth rate of myeloid leukemia, without preventing death, lmmunosuppressive treatment, given before C. parvum, completely blocked the induction of resistance, and if given after C. parvum, abolished the established resistance to lymphatic leukemia. Thus, the danger of immunosuppression accompanying chemotherapy may lie in its abrogating the protective effects of nonspeeifle immunostimulation.

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