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Effect of immunoglobulin G (IgG) interchain disulfide bond cleavage on efficacy of intravenous immunoglobulin for immune thrombocytopenic purpura (ITP)

✍ Scribed by Y. Machino; H. Ohta; E. Suzuki; S. Higurashi; T. Tezuka; H. Nagashima; J. Kohroki; Y. Masuho

Book ID: 108701292
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 610 KB
Volume: 162
Category: Article
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2010.04255.x

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Since in a pilot study i.v. IgG was shown to induce a rapid rise of thrombocytes in children with ITP two prospective multicenter ITP studies were started: one comparing i.v. IgG with oral corticosteroids in previously untreated acute ITP, the other investigating the response to i.v. IgG in pretreat