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Effect of immunocompromise on metastatic cutaneous squamous cell carcinoma in the parotid and neck

✍ Scribed by Katherine E. Southwell; John M. Chaplin; Robert L. Eisenberg; Nicholas P. McIvor; Randall P. Morton

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 77 KB
Volume: 28
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20321

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Our aim was to examine the effect of a compromised immune state on the outcomes in patients treated for metastatic cutaneous squamous cell carcinoma (SCC).

Methods. A retrospective analysis of patients with metastatic cutaneous SCC to the parotid and neck treated at Greenlane Hospital between 1992 and 2002 was conducted. Outcomes were compared between immune-competent and immunocompromised patients. A logistic regression analysis of likely risk factors for poor outcome was done.

Results. Forty-nine patients were identified, nine of whom were immunocompromised. All patients were treated by parotidectomy and/or neck dissection. The facial nerve was sacrificed in 42% of the patients. Thirty-seven patients underwent postoperative radiotherapy (76%). Recurrence was significantly more common in the immunocompromised group (56% vs 28%), with higher rates of local and distant recurrence. Survival at 1 and 2 years was reduced.

Conclusion. Immunocompromise has a significant impact on the outcome of metastatic cutaneous SCC to the parotid and neck, affecting recurrence and survival.

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