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Effect of immobilization stress on anticonvulsant actions and pharmacokinetics of zonisamide in mice

✍ Scribed by Yasuhiko Hashimoto; Katsuya Suemaru; Takahiko Yamamoto; Kenya Kawakami; Hiroaki Araki; Yutaka Gomita

Book ID
114102155
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
140 KB
Volume
68
Category
Article
ISSN
0091-3057

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## Abstract The pharmacokinetics and efficacy of the anticonvulsant primidone (PRM) and its active metabolites, phenobarbital (PB) and phenylethylmalonamide (PEMA), were studied after single‐dose administration in mice. The half‐life of PB is twice that of PRM and PEMA. The plasma/brain ratios prov