Effect of hypophysectomy, isletectomy and ACTH on glycemia and hematocrit in the bullhead,Ictalurus melas

✍ Scribed by Chidambaram, S. ;Meyer, R. K. ;Hasler, A. D.

• Book ID: 102335872
• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 500 KB
• Volume: 184
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401840106

✦ Synopsis

Abstract

Effect of hypophysectomy, isletectomy and ACTH on glycemia and hematocrit in Ictalurus melas were studied. The mean blood glucose (BG) and hematocrit in intact untreated fish were found to be 69.65 mg/100 ml and 33.7% respectively. Following hypophysectomy there was a 73.1% decrease in BG and a 50% decrease in the hematocrit. Changes in sham‐operated controls were insignificant.

Eight IU of porcine ACTH administered in two injections on days 6 and 8 post‐hypophysectomy increased the BG to pre‐hypophysectomy level and the hematocrit to 70% of its initial value on day 9, whereas in vehicle injected controls BG and hematocrit values remained at their post‐hypophysectomy level.

Isletectomy caused hyperglycemia in all the experimental animals. It induced a net increase of 142.3% over the pretreatment BG compared to 5.2% increase in sham‐operated controls. Isletectomy unlike hypophysectomy did not produce any significant change in the hematocrit.