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Effect of hypercapnia and/or hypoxemia and metabolic acidosis on kinetics and concentrations of phenytoin in the cerebrospinal fluid of conscious rabbits

✍ Scribed by P. Du Souich; F. Varin; Hélène Courteau

Book ID
118955389
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
635 KB
Volume
25
Category
Article
ISSN
0028-3908

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✍ I. Okabe; H. Kodama; H. Shimoizumi; S. Kamoshita; S. Miyabayashi 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 89 KB

Sir: Dichloroacetate (DCA, 15-20 mg/kg per day) was given orally twice daily to a 12-mouth-old boy with congenital lactic acidosis [1,3]. The clinical and laboratory findings were compatible with Leigh syndrome [2]. Enzyme activities associated with lactate metabolism were normal in his fibroblasts