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Effect of hydroxyurea and 5-fluorodeoxy-uridine on deoxyribonucleoside triphosphate pools early in phytohemagglutinin-stimulated human lymphocytes

โœ Scribed by Gerda Tyrsted


Book ID
115776076
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
716 KB
Volume
31
Category
Article
ISSN
0006-2952

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Effect of 5-fluoro-2โ€ฒ-deoxyuridine and h
โœ Gerda Tyrsted ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 623 KB

The inhibitors of DNA synthesis, 5-fluoro-2'-deoxyuridine and hydroxyurea, caused an inhibition of thymidine kinase, replicative DNA polymerase and CDP reductase activities in stimulated lymphocytes when they were exposed to the inhibitors during the early transformation period (0-17 hr). However, t