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Effect of host strain and H-2 type on spontaneous regression of murine leukemia

✍ Scribed by Michael Dietz; Marvin A. Rich

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
411 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The susceptibility of 14 mouse strains to a regressing and a conventional strain of Friend leukemia virus was studied. A comparison of leukemia incidence and latent period to leukemia development demonstrated that, for all mouse strains, the susceptibility to both viruses was the same.

Leukemia regression occurred in 10 of the 12 mouse strains susceptible to regressing Friend virus (RFV). Regression of leukemia in mice inoculated with conventional Friend Virus (CFV) occurred primarily in those mouse strains homozygous for the H‐2^k^ allele. RFV‐induced leukemia regression was observed in mice homozygous for H‐2^a^, H‐2^q^, H‐2^s^, H‐2^d^, and H‐2^k^. The H‐2 locus does not appear to be a determinant in leukemia regression.

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