Effect of hormones and environmental factors on lactic dehydrogenases

✍ Scribed by Kaplan, Nathan O.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1965
• Tongue: English
• Weight: 735 KB
• Volume: 66
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030660403

✦ Synopsis

There are two types (M and H) of lactic dehydrogenase that are found in most animals. The M-type i s found largely in the more anaerobic tissues, such as voIuntary skeletal muscles; the H-type is found in aerobic tissues, such as cardiac muscle. In the immature uterus, the level of M units is considerably less than that found in the mature uterus. Injection of estradiol leads to a marked increase in M units in the immature uterus, but there is no significant change in the concentration of the H form. Testosterone and progesterone, in contrast, promote a proportional increase i n the two lactic dehydrogenases in the immature uterus. Testosterone, however, induces a selective synthesis of M units in the seminal vessels of the immature rat. Hypophysectomy leads to a decrease in M units of skeletal muscle. The effects of various hormones on the composition of lactic dehydrogenase of the rat and chicken will be summarized.

CELL. AND COMP.