✦ LIBER ✦

Effect of HLA mismatches on the outcome of hematopoietic transplants

✍ Scribed by Effie W Petersdorf; Eric M Mickelson; Claudio Anasetti; Paul J Martin; Ann E Woolfrey; John A Hansen

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 85 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00016-3

No coin nor oath required. For personal study only.

✦ Synopsis

Hematopoietic cell transplantation from unrelated volunteer donors for the treatment of hematological malignancy can be optimized by complete and precise matching for HLA class I and II alleles between the donor and recipient. Survival is improved when the donor and recipient are matched for HLA-A, -B, -C, -DRB, -DQB1 and -DPB1 alleles. The risks of clinically severe graft-versus-host disease, graft failure and mortality are increased in the presence of multilocus mismatching. These findings demonstrate that HLA allelic differences are biologically relevant in human transplantation.

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