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Effect of high-density lipoprotein on neutral cholesteryl ester hydrolase activity in rat hepatoma cells

โœ Scribed by A. Shimada; T. Tamai; J. Suzuki; T. Nakai; K. Oida; S. Takahashi; S. Miyabo

Book ID
118325156
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
151 KB
Volume
109
Category
Article
ISSN
0021-9150

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## Abstract Diethylumbelliferyl phosphate (UBP) has been shown to inhibit the neutral cholesteryl ester hydrolase activity responsible for hydrolysis of cellular lipid droplet cholesteryl ester (Harrison et al., 1990). The potential for (UBP) to inhibit uptake and hydrolysis of high density lipopro

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Rat hepatoma cells (Fu5AHj were studied as a model for the net delivery of apoE-free high-density lipoprotein (HDL) cholesterol to a cell. Incubating cells with HDL results in 1) a decrease in both media-free cholesterol and cholesteryl ester concentration; 2) decreased cell sterol synthesis; and 3)